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Homeostatic Plasticity

Neurons adapt their synaptic and intrinsic properties in response to changes in network activity. However, despite these changes stability of neuronal networks must be assured. We are interested in better understanding the cellular and molecular mechanisms, which control the ability of neurons to maintain stability under physiological and pathological conditions. Augmenting this ability of neurons to compensate could increase the ‘homeostatic resilience’ of neural networks to pathological stimuli.

 

Maggio N, Vlachos A° (2014) Synaptic plasticity at the interface of health and disease: new insights on the role of endoplasmic reticulum intracellular calcium stores. Neuroscience. 281C: 135-146.

Vlachos A°, Ikenberg B, Lenz M, Becker D, Reifenberg K, Bas Orth C, Deller T (2013). Synaptopodin regulates denervation-induced homeostatic synaptic plasticity. Proc Natl Acad Sci USA. 110: 8242-7.

Vlachos A*, Reddy-Alla S*, Papadopoulos T, Deller T, Betz H° (2013). Homeostatic regulation of gephyrin scaffolds and synaptic strength at mature hippocampal GABAergic postsynapses. Cereb Cortex. 23: 2700-2711.

Vlachos A°, Becker D, Jedlicka P, Winkels R, Roeper J, Deller T (2012). Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures. PLoS One. 7: e32883.